In a large mixing bowl, combine the ground beef, garlic powder, onion powder, salt, and black pepper. Use your hands to gently mix the ingredients until just combined; avoid overmixing to keep the burgers tender.

Divide the mixture into four equal portions and shape each portion into a patty, about 3/4 inch thick. Make a slight indentation in the center of each patty to prevent them from puffing up while cooking.

Preheat a grill or skillet over medium-high heat. Cook the patties for about 4-5 minutes on one side, then flip and cook for an additional 3-4 minutes for medium doneness. Adjust cooking time according to your preferred doneness.

If using cheese, place a slice on each patty during the last minute of cooking to melt.

Remove the burgers from the heat and let them rest for a few minutes before serving.