Preheat your oven to 400°F (200°C).
Pat the salmon fillets dry with paper towels and season both sides with salt, pepper, garlic powder, and smoked paprika.
In a large oven-safe skillet, heat the olive oil over medium-high heat. Once hot, add the salmon fillets skin-side down and cook for 4-5 minutes until the skin is crispy.
Carefully flip the salmon fillets and transfer the skillet to the preheated oven. Bake for an additional 5-7 minutes, or until the salmon is cooked through and flakes easily with a fork.
While the salmon is baking, prepare the roasted red pepper sauce. In a blender, combine the roasted red peppers, heavy cream, lemon juice, and red pepper flakes (if using). Blend until smooth.
Pour the sauce into a small saucepan and heat over medium-low heat until warmed through, stirring occasionally.
Once the salmon is done, remove it from the oven and serve immediately with the warm roasted red pepper sauce drizzled on top. Garnish with fresh parsley.